Factor V Leiden and other coagulation factor mutations affecting thrombotic risk
نویسندگان
چکیده
منابع مشابه
Factor V Leiden and other coagulation factor mutations affecting thrombotic risk.
Five genetic defects have been established as risk factors for venous thrombosis. Three are protein C, protein S, and antithrombin deficiencies, defects in the anticoagulant pathways of blood coagulation. Together they can be found in approximately 15% of families with inherited thrombophilia. Their laboratory diagnosis is hampered by the large genetic heterogeneity of these defects. The other ...
متن کاملthe association of coagulation factor v (leiden) and factor ii (prothrombin) mutations with stroke
conclusions the prevalence of both fv and fii variants are population based. iran is an ethnically diverse country. therefore, for a comprehensive analysis of a potential association of fv and/or fii mutations with stroke among iranian population, epidemiological studies could be conducted among different ethnic groups. patients and methods the study population consisted of 153 patients of diff...
متن کاملThe Association of Coagulation Factor V (Leiden) and Factor II (Prothrombin) Mutations With Stroke
BACKGROUND Epidemiological studies indicate that over the past forty years, the stroke incidence rates has increased. Factors V and II mutations are established genetic-variant risk factors for venous thrombosis; however, their contribution to stroke is a controversial issue. OBJECTIVES This study aimed to investigate the potential association of FV and FII mutations with stroke in an Iranian...
متن کاملIs factor V Leiden a risk factor for thrombotic microangiopathies without severe ADAMTS 13 deficiency?
About 60% of patients diagnosed with acute thrombotic thrombocytopenic purpura (TTP) display a severe ADAMTS13 deficiency. Recently, Raife et al. concluded from a small case series, that factor V Leiden (FVL) might constitute a risk factor for acute thrombotic microangiopathy (TMA) without severe ADAMTS13 deficiency. Therefore, we determined ADAMTS13 activity and FVL carrier-ship in 256 consecu...
متن کاملFactor V Leiden and perioperative risk.
Factor V Leiden (FVL) is the most common known inherited cause of thrombophilia; it is present in approximately 5% of the Caucasian population. Although the risk of venous thrombosis associated with this polymorphism in various medical settings is well described, its effect on perioperative risk is only beginning to be explored. Specifically, there are few studies addressing the potential risks...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1997
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/43.9.1678